Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management / Edition 2

ISBN-13:	9780521875196
Publisher:	Cambridge University Press
Publication date:	08/17/2009
Series:	Cambridge Medicine (Hardcover)
Edition description:	New Edition
Pages:	846
Sales rank:	752,896
Product dimensions:	8.40(w) x 11.10(h) x 1.70(d)

This book is a completely revised new edition of the definitive reference on disorders of hemoglobin. Authored by world-renowned experts, the book focuses on basic science aspects and clinical features of hemoglobinopathies, covering diagnosis, treatment, and future applications of current research. While the second edition continues to address the important molecular, cellular, and genetic components, coverage of clinical issues has been significantly expanded, and there is more practical emphasis on diagnosis and management throughout. The book opens with a review of the scientific underpinnings. Pathophysiology of common hemoglobin disorders is discussed next in an entirely new section devoted to vascular biology, the erythrocyte membrane, nitric oxide biology, and hemolysis. Four sections deal with α and β thalassemia, sickle cell disease, and related conditions, followed by special topics. The second edition concludes with current and developing approaches to treatment, incorporating new agents for iron chelation, methods to induce fetal hemoglobin production, novel treatment approaches, stem cell transplantation, and progress in gene therapy.